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Abstract Detail



Evolution of Plant Chemical Diversity: Renaissance of comparative biochemistry

Wisecaver, Jennifer [1].

Linking genes to lineage-specific metabolic pathways: Gene network analysis of glucosinolate biosynthesis in Brassicaceaes.

Specialized metabolites serve myriad biological functions that allow organisms to interact with and manage their environment (e.g., resist abiotic stress, combat negative ecological interactions and promote beneficial ones). As these specialized metabolites are typically fast-evolving and lineage-specific, the genes and pathways involved in their biosynthesis are often unknown, hampering our ability to understand their function and evolutionary history. Critically, this also limits the potential utility of specialized metabolites in agricultural, pharmaceutical, and biotechnological applications. Brassicaceaes produce numerous specialized metabolites including glucosinolates (pungent glucosides that contribute to the family’s distinctive taste), which are associated with numerous ecologically advantageous traits including resistance to pests, drought, freezing, and heavy metals. By leveraging network biology to delineate specialized metabolic pathways coupled with evolutionary genomics to untangle pathway origins and diversification, we are investigatinghow gene duplication, regulatory network/genome rearrangement, and polyploidy contribute to metabolic diversity and innovation.


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1 - Purdue University, Biochemistry, Center for Plant Biology, West Lafayette, IN, USA

Keywords:
Specialized metabolism
Natural Products
gene family evolution
co-expression network.

Presentation Type: Symposium Presentation
Session: SY5, Evolution of Plant Chemical Diversity: Renaissance of comparative biochemistry
Location: 102/Mayo Civic Center
Date: Wednesday, July 25th, 2018
Time: 11:15 AM
Number: SY5008
Abstract ID:683
Candidate for Awards:None


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